HRS is a life-threatening complication that may occur in patients with advanced liver disease.1 HRS is classified into two distinct types – hepatorenal syndrome type-1 and type-2.1 Hepatorenal syndrome type 1 (HRS-1) is a rapidly progressive condition that leads to renal failure.1 It is often a challenge to effectively diagnose in a timely manner due to its diagnosis of exclusion.2
The Premier Healthcare Database, a
"Hepatorenal syndrome is difficult to diagnose and typically met with high mortality rates if left untreated. Identifying the disease from a large national hospital database, although with limitations, is important as it enables us to understand national practice patterns and outcomes," said
HRS-1 has a median survival time of approximately two weeks and greater than 80 percent mortality within three months if left untreated.2,4 At present, there are no drug therapies approved for the treatment of HRS-1 in the
"The work of
The study was funded by Mallinckrodt.
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This release includes forward-looking statements with regard to the study described in this release, including its potential impact on patients. The statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those in the forward-looking statements: satisfaction of regulatory and other requirements; actions of regulatory bodies and other governmental authorities; changes in laws and regulations; issues with product quality, manufacturing or supply, or patient safety issues; and other risks identified and described in more detail in the "Risk Factors" section of Mallinckrodt's most recent Annual Report on Form 10-K and other filings with the
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1 National Organization for Rare Disorders. Hepatorenal Syndrome. Available at: https://rarediseases.org/rare-diseases/hepatorenal-syndrome/. Accessed
2 Gines P, Sola E, Angeli P, et al. Hepatorenal syndrome. Nature Reviews. 2018; 4:23.
3 Allegretti A, Böing E, Ahn S, Zhou H, Jamil K, Cort S, Huang X. Hepatorenal syndrome and acute kidney injury in patients with liver disease: National practice patterns and outcomes from a large
4 Colle I and Laterre PF. Hepatorenal syndrome: the clinical impact of vasoactive therapy. Expert Review of Gastroenterology & Hepatology. (2018) 12:2, 173-188, DOI: 10.1080/17474124.2018.1417034.
5 Boyer TD, Medicis JJ, Pappas SC, et al. A randomized, placebo-controlled, double-blind study to confirm the reversal of hepatorenal syndrome type 1 with terlipressin: the REVERSE trial design. Open Access Journal of Clinical Trials 2012:4. https://www.dovepress.com/a-randomized-placebo-controlled-double-blind-study-to-confirm-the-reve-peer-reviewed-article-OAJCT.
6 C Pant, B S Jani, M Desai, A Deshpande,
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